A novel chimeric Newcastle disease virus vectored vaccine against highly pathogenic avian influenza virus
نویسندگان
چکیده
منابع مشابه
Newcastle disease virus-vectored vaccines expressing the hemagglutinin or neuraminidase protein of H5N1 highly pathogenic avian influenza virus protect against virus challenge in monkeys.
H5N1 highly pathogenic avian influenza virus (HPAIV) causes periodic outbreaks in humans, resulting in severe infections with a high (60%) incidence of mortality. The circulating strains have low human-to-human transmissibility; however, widespread concerns exist that enhanced transmission due to mutations could lead to a global pandemic. We previously engineered Newcastle disease virus (NDV), ...
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Author affiliations: Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany (I.A. Asante, S. Bertram, G. Gabriel); Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana (I.A. Asante, W.K. Ampofo); Center for Structural and Cellular Biology in Medicine at the University of Lübeck, Lübeck, Germany (S. Bertram, G. Gabriel); Veterinary S...
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Newcastle disease virus (NDV) strain F is a lentogenic vaccine strain used for primary vaccination in day-old chickens against Newcastle disease (ND) in India and Southeast Asian countries. Recombinant NDV-F virus and another recombinant NDV harboring the major capsid protein VP2 gene of a very virulent infectious bursal disease virus (IBDV); namely rNDV-F and rNDV-F/VP2, respectively, were gen...
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BACKGROUND Highly-pathogenic avian influenza virus (HPAIV) and Newcastle disease virus (NDV) are the two most important poultry viruses in the world. Natural low-virulence NDV strains have been used as vaccines over the past 70 years with proven track records. We have previously developed a reverse genetics system to produce low-virulent NDV vaccine strain LaSota from cloned cDNA. This system a...
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Because fatal infections with highly pathogenic avian influenza A (HPAI) virus subtype H5N1 have been reported in birds of prey, we sought to determine detailed information about the birds' susceptibility and protection after vaccination. Ten falcons vaccinated with an inactivated influenza virus (H5N2) vaccine seroconverted. We then challenged 5 vaccinated and 5 nonvaccinated falcons with HPAI...
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ژورنال
عنوان ژورنال: Virology
سال: 2017
ISSN: 0042-6822
DOI: 10.1016/j.virol.2017.01.006